IGF-1 cohort study 2017 men
A cohort of 14 hypogonadal men on testosterone reported raised serum IGF-1 levels after growth hormone secretagogue therapy including sermorelin over 134 days. Reported in the cited paper.
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Growth Hormone
Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of growth hormone releasing hormone. It was once approved as Geref for paediatric use but was withdrawn from the United States market in 2008, and now circulates mainly through compounding pharmacies.
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Overview
What is Sermorelin?
Sermorelin is a synthetic analogue of the first 29 amino acids of growth hormone releasing hormone. It was once approved as Geref for paediatric use but was withdrawn from the United States market in 2008, and now circulates mainly through compounding pharmacies.
- GH Support
- Sleep Quality
- Recovery
- Body Composition
What the research reports
Reported benefits of Sermorelin
Outcomes described across the published Sermorelin literature and ongoing study. Read each as research context rather than a promised personal result.
- 01
Physiological GH pulse release
Acts on the pituitary as a GHRH analogue, so release follows the body's own pulsatile pattern rather than overriding it. Reported in research settings.
- 02
IGF-1 elevation in cohorts
A 2017 cohort of 14 hypogonadal men on testosterone reported raised serum IGF-1 after growth hormone secretagogue therapy. Reported in research settings.
- 03
Nighttime dosing rationale
Dosed before bed to amplify the natural overnight growth hormone pulse, which is the basis of most published protocols. Reported in research settings.
- 04
Short acting release profile
The 10 to 20 minute half-life means exposure is brief, which is often presented as a safety argument for this class. Described in the research record.
- 05
Long clinical familiarity
The molecule has been in clinical use since the 1980s, giving prescribers a longer familiarity than most research peptides. Reported in research settings.
Dosage and protocol
How Sermorelin is typically studied
Protocols use 100 to 300 mcg before bed, or 100 to 200 mcg twice daily, across 3 to 6 months. The half-life is 10 to 20 minutes. Figures describe study protocols, not a personal regimen.
- Route
- Subcutaneous injection
- Example range
- 200-300 mcg
- Frequency
- Once daily before bed
- Timing
- Before bed on an empty stomach to amplify the natural nighttime GH pulse. Refrigerate after mixing.
Clinical evidence
Clinical evidence for Sermorelin
The published record for Sermorelin, labeled by strength so you can see what is settled and what is emerging.
Adult GH insufficiency review
A 2006 review argued sermorelin may be a better approach to adult onset growth hormone insufficiency than direct growth hormone replacement. Reported in the cited paper.
SourceFalsified injectables report
A 2016 review of seizures across Europe found sermorelin among falsified biopharmaceutical injectables, a supply chain warning rather than efficacy data. Reported in the cited paper.
SourceInteractions
How Sermorelin pairs with other peptides
- MK-677 oral
- Stacking growth hormone secretagogues raises IGF-1 and insulin resistance risk. Use lower doses if combined.
- Ipamorelin
- GHRH analogue plus ghrelin mimetic amplifies the pulse, but also raises total IGF-1 exposure.
- Tesamorelin
- Both are GHRH analogues on the same receptor, so combining duplicates one mechanism without benefit.
- Corticosteroids
- Steroid therapy can blunt the pituitary response and reduce the growth hormone pulse achieved.
Questions
Frequently asked questions.
What is Sermorelin?
Sermorelin is a peptide compound used in research settings. It is commonly studied for its role in growth hormone, and many researchers compare supplier quality, purity, and testing data before purchasing.
What are the research benefits of Sermorelin?
Sermorelin is often evaluated for its potential influence on signaling pathways, recovery support, and targeted research applications. Research interest varies by peptide, formulation, and study design, so buyers typically review purity, dose, and independent lab verification before choosing a source.
How does Sermorelin work?
Like other research peptides, Sermorelin is typically studied for how it interacts with specific biological pathways and receptor systems. In practice, the way it is formulated, dosed, and tested matters as much as the compound itself, which is why verified suppliers and transparent COAs are important.
Is Sermorelin for research use only?
Yes, products like Sermorelin are generally intended for research, laboratory, or educational use and are not marketed as approved human therapeutics. Always follow local laws, lab safety practices, and institutional requirements before handling or studying any peptide.
What should I look for before buying Sermorelin?
Key checks include verified COA data, peptide form and concentration, supplier reputation, stock status, and cost per mg. Comparing pricing and testing records side-by-side helps reduce the risk of buying an under-tested or misrepresented product.
