Semax

Overview

What is Semax?

Semax is a synthetic heptapeptide derived from ACTH(4-10), registered as a nootropic and neuroprotective medicine in Russia. It's studied for stroke recovery, cognitive function, and optic nerve conditions, and is frequently compared alongside Selank, another Russian-developed research peptide.

• Cognitive Support
• Neuroprotection
• Focus
• Memory

What the research reports

Reported benefits of Semax

Outcomes described across the published Semax literature and ongoing study. Read each as research context rather than a promised personal result.

1. 01

   Cognitive research interest

   Studied in Russia for cognitive disorders and stroke recovery, where it is a registered medicine rather than an unapproved compound. Reported in research settings.

2. 02

   Brain connectivity changes

   A 2018 randomised fMRI study reported increased default mode network volume in the medial frontal cortex against placebo. Reported in research settings.

3. 03

   Neuroprotection study record

   Animal work describes reduced ischemic damage, which underpins the stroke recovery indication in its country of registration. Reported in research settings.

4. 04

   Neurogenesis signalling work

   Published work describes effects on neurogenesis and progenitor cell proliferation, alongside modulation of neurotransmitter systems. Reported in research settings.

5. 05

   Rapid onset by nasal route

   Intranasal administration is reported to produce measurable effects within 15 to 30 minutes in the cited research.

Clinical evidence

Semax clinical evidence summary

The published Semax record, labeled by strength so you can see what is settled and what is still emerging.

Interactions

How Semax pairs with other peptides

Selank peptide

Neutral to mildly synergistic. Different neurological targets with no known negative interaction.

Stimulants

Both raise alertness, so combining may compound restlessness or blood pressure effects in some people.

Blood pressure drugs

Semax may affect blood pressure in some individuals, which matters alongside antihypertensive therapy.

Dihexa peptide

Both are studied for cognition by separate mechanisms, with no data on combined administration.