NAD+

Overview

What is NAD+?

NAD+ is a coenzyme present in every cell, central to energy metabolism, DNA repair and sirtuin signalling. It is not a peptide. Supplemental forms include intravenous infusion, subcutaneous injection and oral precursors such as NMN and nicotinamide riboside.

• Cellular Energy
• DNA Repair
• Longevity
• Metabolic Health

What the research reports

Reported benefits of NAD+

Outcomes described across the published NAD+ literature and ongoing study. Read each as research context rather than a promised personal result.

1. 01

   Cellular energy metabolism

   Sits at the centre of mitochondrial energy production, acting as the electron carrier that drives ATP generation in every cell. Reported in research settings.

2. 02

   DNA repair pathway support

   Serves as substrate for PARP enzymes involved in DNA repair, which is the mechanistic basis for most longevity interest. Reported in research settings.

3. 03

   Sirtuin activation dependency

   Sirtuins depend on NAD+ as a cofactor, linking its availability to pathways associated with cellular ageing in laboratory work. Reported in research settings.

4. 04

   Age related NAD+ level decline

   A cohort of 1,518 people found whole blood NAD+ declines with age in males, with a notable drop in the 40 to 49 group. Described in the research record.

5. 05

   Clinic based infusion use

   Intravenous protocols have become common in wellness and longevity clinics, though controlled efficacy trials remain absent. Reported in research settings.

Dosage and protocol

How NAD+ is typically studied

Protocols use 250 to 1000 mg intravenously, 50 to 200 mg subcutaneously, or oral precursors at 250 to 1000 mg of NMN daily. Figures describe study protocols, not a personal regimen.

Route

Intravenous or oral route

Example range

500 mg IV

Frequency

Daily for three to five days

Timing

Infuse slowly across two to four hours. Rapid infusion causes chest tightness, nausea and cramping.

Clinical evidence

NAD+ clinical evidence summary

The published NAD+ record, labeled by strength so you can see what is settled and what is still emerging.

Interactions

How NAD+ pairs with other peptides

MOTS-c peptide

Synergistic for mitochondrial function. Both act on cellular energy pathways by complementary routes.

5-Amino-1MQ

NNMT inhibition affects nicotinamide handling, so spacing the two apart is commonly suggested.

Resveratrol

Often paired on the theory of sirtuin support, although controlled human data for the pairing is absent.

Alcohol intake

Alcohol metabolism consumes NAD+, so heavy intake works against the stated purpose of supplementation.