CJC-1295 without DAC, also called modified GRF 1-29, is a short acting GHRH analogue that stimulates pulsatile growth hormone release. Removing the drug affinity complex shortens its action to around 30 minutes, so it is often paired in research settings with a ghrelin mimetic such as ipamorelin to extend the effect.
CJC-1295 without DAC, also called modified GRF 1-29, is a short acting GHRH analogue that stimulates pulsatile growth hormone release. Removing the drug affinity complex shortens its action to around 30 minutes, so it is often paired in research settings with a ghrelin mimetic such as ipamorelin to extend the effect.
GH Support
Recovery
Body Composition
Sleep Quality
What the research reports
Benefits of CJC-1295 (No DAC)
Outcomes described across the published CJC-1295 (No DAC) literature and ongoing study. Read each as research context, not a promised result.
01
Pulsatile GH stimulation work
Acts on the pituitary GHRH receptor to raise growth hormone while preserving the body's own pulse pattern rather than flattening it. Reported in research settings.
02
Pairs with ghrelin mimetics
The short acting form is usually combined with ipamorelin, where the two pathways together produce a larger pulse than either alone. Reported in research settings.
03
Shorter drug exposure window
Without the drug affinity complex the action lasts roughly 30 minutes, so IGF-1 does not stay elevated between doses. Described in the research record.
04
Dose flexibility in protocols
The brief action means research use typically involves multiple smaller pulses across a day rather than one sustained level, mirroring the body's own episodic GH release pattern.
05
Established GHRH mechanism
The parent molecule with DAC raised growth hormone and IGF-1 dose dependently in healthy adults in a published phase 1 programme. Reported in research settings.
Clinical evidence
Clinical evidence and study base
The published record, labeled by strength so you can see what is settled and what is still emerging.
CJC-1295 phase 1 human study
A 2006 trial of the long-acting DAC form of CJC-1295 reported sustained, dose-dependent increases in growth hormone and IGF-1 in healthy adults, well tolerated at doses up to 180 mcg/kg. This trial tested the DAC version; it does not describe the no-DAC form on this page, which clears the body in roughly 30 minutes rather than producing a sustained effect.
No published clinical trial has tested the shorter acting no DAC version on its own. Human data comes from the DAC form and general GHRH research. Reported in the cited paper.
A 2017 cohort in hypogonadal men reported raised serum IGF-1 after growth hormone secretagogue therapy, the closest human outcome data for this class. Reported in the cited paper.
Synergistic for GH release. GHRH analogue plus ghrelin mimetic amplifies the pulse through two pathways.
GHRP-2 peptide
Also synergistic, though GHRP-2 adds more appetite, cortisol and prolactin effect than ipamorelin does.
BPC-157 peptide
No known negative interaction. Tissue repair and growth hormone release act on separate systems.
MK-677 oral
Stacking secretagogues compounds IGF-1 elevation and the insulin resistance risk associated with GH-axis activation; this is a known pharmacological interaction, not dosing guidance.
Questions
Frequently asked questions.
What is CJC-1295 (No DAC)?
CJC-1295 without DAC, also known as Modified GRF (1-29), is a synthetic peptide fragment of growth hormone-releasing hormone (GHRH). Removing the drug affinity complex (DAC) shortens its activity to roughly 30 minutes, unlike the long-acting DAC version.
What are the research benefits of CJC-1295 (No DAC)?
Research has explored its ability to stimulate pulsatile growth hormone release from the pituitary while preserving the body's natural pulse pattern, and its use alongside ghrelin-mimetic peptides to produce a combined GH response, though direct clinical trial data on the no-DAC form specifically remains limited.
How does CJC-1295 (No DAC) work?
It binds the GHRH receptor on the pituitary gland, prompting a short, defined pulse of growth hormone release. Because it lacks the DAC's drug-binding extension, it clears the body quickly rather than producing a sustained elevation.
Is CJC-1295 (No DAC) for research use only?
Yes. CJC-1295 (No DAC) is sold and discussed here strictly for laboratory and research purposes. PepLookup does not provide dosing, administration, or protocol guidance for any compound; consult the primary literature cited in the Evidence section above.
What should I look for before buying CJC-1295 (No DAC)?
Check for third-party Certificate of Analysis (COA) results confirming identity and purity, confirm the supplier specifies "No DAC" rather than the long-acting DAC form, and compare pricing and documentation across the suppliers listed on this page before choosing a source.