Default mode network study
A 2018 randomised fMRI study in 24 participants reported increased default mode network volume in the medial frontal cortex against placebo after dosing. Reported in the cited paper.
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Cognitive
Semax
Semax is a synthetic heptapeptide based on a fragment of ACTH with modifications that improve stability and brain penetration. Developed in Russia and registered there for stroke and cognitive disorders, it is not approved in the United States or Europe.
- Lowest cost / mg
- $0.37/mg
- at Ares Research Lab
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- 66
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Overview
What is Semax?
Semax is a synthetic heptapeptide based on a fragment of ACTH with modifications that improve stability and brain penetration. Developed in Russia and registered there for stroke and cognitive disorders, it is not approved in the United States or Europe.
- Cognitive Support
- Neuroprotection
- Focus
- Memory
What the research reports
Reported benefits of Semax
Outcomes described across the published Semax literature and ongoing study. Read each as research context rather than a promised personal result.
- 01
Cognitive research interest
Studied in Russia for cognitive disorders and stroke recovery, where it is a registered medicine rather than an unapproved compound. Reported in research settings.
- 02
Brain connectivity changes
A 2018 randomised fMRI study reported increased default mode network volume in the medial frontal cortex against placebo. Reported in research settings.
- 03
Neuroprotection study record
Animal work describes reduced ischemic damage, which underpins the stroke recovery indication in its country of registration. Reported in research settings.
- 04
Neurogenesis signalling work
Published work describes effects on neurogenesis and progenitor cell proliferation, alongside modulation of neurotransmitter systems. Reported in research settings.
- 05
Rapid onset by nasal route
Intranasal administration is reported to produce effects within 15 to 30 minutes, which shapes how protocols are timed. Reported in research settings.
Dosage and protocol
How Semax is typically studied
Protocols use 200 to 600 mcg daily intranasally, split across one or two doses, for 10 to 20 days before a break. Figures describe study protocols, not a personal regimen.
- Route
- Intranasal or injection
- Example range
- 200-300 mcg
- Frequency
- One to two times daily
- Timing
- Morning or early afternoon. Onset within 15 to 30 minutes intranasally.
Clinical evidence
Semax clinical evidence summary
The published Semax record, labeled by strength so you can see what is settled and what is still emerging.
Connectomic comparison, 2020
A randomised study in 52 participants reported distinct functional connectivity changes in amygdala and prefrontal regions for semax against selank. Reported in the cited paper.
SourceOptic neuropathy trial, 2022
A Russian randomised trial in 60 patients reported 83 to 94 percent efficacy for visual field and light sensitivity, with semax inside a combined protocol. Reported in the cited paper.
SourceInteractions
How Semax pairs with other peptides
- Selank peptide
- Neutral to mildly synergistic. Different neurological targets with no known negative interaction.
- Stimulants
- Both raise alertness, so combining may compound restlessness or blood pressure effects in some people.
- Blood pressure drugs
- Semax may affect blood pressure in some individuals, which matters alongside antihypertensive therapy.
- Dihexa peptide
- Both are studied for cognition by separate mechanisms, with no data on combined administration.
Questions
Frequently asked questions.
What is Semax?
Semax is a peptide compound used in research settings. It is commonly studied for its role in cognitive, and many researchers compare supplier quality, purity, and testing data before purchasing.
What are the research benefits of Semax?
Semax is often evaluated for its potential influence on signaling pathways, recovery support, and targeted research applications. Research interest varies by peptide, formulation, and study design, so buyers typically review purity, dose, and independent lab verification before choosing a source.
How does Semax work?
Like other research peptides, Semax is typically studied for how it interacts with specific biological pathways and receptor systems. In practice, the way it is formulated, dosed, and tested matters as much as the compound itself, which is why verified suppliers and transparent COAs are important.
Is Semax for research use only?
Yes, products like Semax are generally intended for research, laboratory, or educational use and are not marketed as approved human therapeutics. Always follow local laws, lab safety practices, and institutional requirements before handling or studying any peptide.
What should I look for before buying Semax?
Key checks include verified COA data, peptide form and concentration, supplier reputation, stock status, and cost per mg. Comparing pricing and testing records side-by-side helps reduce the risk of buying an under-tested or misrepresented product.
