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Anti-Aging

NAD+

NAD+ is a coenzyme present in every cell, central to energy metabolism, DNA repair and sirtuin signalling. It is not a peptide. Supplemental forms include intravenous infusion, subcutaneous injection and oral precursors such as NMN and nicotinamide riboside.

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Independent third-party laboratory analysis for quality assurance.

Tracked tests93 Reports

Overview

What is NAD+?

NAD+ is a coenzyme present in every cell, central to energy metabolism, DNA repair and sirtuin signalling. It is not a peptide. Supplemental forms include intravenous infusion, subcutaneous injection and oral precursors such as NMN and nicotinamide riboside.

  • Cellular Energy
  • DNA Repair
  • Longevity
  • Metabolic Health

What the research reports

Reported benefits of NAD+

Outcomes described across the published NAD+ literature and ongoing study. Read each as research context rather than a promised personal result.

  1. 01

    Cellular energy metabolism

    Sits at the centre of mitochondrial energy production, acting as the electron carrier that drives ATP generation in every cell. Reported in research settings.

  2. 02

    DNA repair pathway support

    Serves as substrate for PARP enzymes involved in DNA repair, which is the mechanistic basis for most longevity interest. Reported in research settings.

  3. 03

    Sirtuin activation dependency

    Sirtuins depend on NAD+ as a cofactor, linking its availability to pathways associated with cellular ageing in laboratory work. Reported in research settings.

  4. 04

    Age related NAD+ level decline

    A cohort of 1,518 people found whole blood NAD+ declines with age in males, with a notable drop in the 40 to 49 group. Described in the research record.

  5. 05

    Clinic based infusion use

    Intravenous protocols have become common in wellness and longevity clinics, though controlled efficacy trials remain absent. Reported in research settings.

Dosage and protocol

How NAD+ is typically studied

Protocols use 250 to 1000 mg intravenously, 50 to 200 mg subcutaneously, or oral precursors at 250 to 1000 mg of NMN daily. Figures describe study protocols, not a personal regimen.

Route
Intravenous or oral route
Example range
500 mg IV
Frequency
Daily for three to five days
Timing
Infuse slowly across two to four hours. Rapid infusion causes chest tightness, nausea and cramping.

Clinical evidence

NAD+ clinical evidence summary

The published NAD+ record, labeled by strength so you can see what is settled and what is still emerging.

Blood NAD+ levels and ageing

A 2022 cohort of 1,518 people reported that whole blood NAD+ content declines with age in males, with a significant drop in the 40 to 49 age group. Reported in the cited paper.

Source

Ageing biomarker panel study

A 2023 cohort of 169 healthy individuals assessed NAD+ alongside sirtuin 1, klotho and other markers, reporting variation by age and by sex. Reported in the cited paper.

Source

No supplementation trials

The listed studies measure NAD+ as it varies naturally rather than testing supplementation, so clinical efficacy data remains preliminary. Reported in the cited paper.

Source

Interactions

How NAD+ pairs with other peptides

MOTS-c peptide
Synergistic for mitochondrial function. Both act on cellular energy pathways by complementary routes.
5-Amino-1MQ
NNMT inhibition affects nicotinamide handling, so spacing the two apart is commonly suggested.
Resveratrol
Often paired on the theory of sirtuin support, although controlled human data for the pairing is absent.
Alcohol intake
Alcohol metabolism consumes NAD+, so heavy intake works against the stated purpose of supplementation.

Questions

Frequently asked questions.

What is NAD+?
NAD+ is a peptide compound used in research settings. It is commonly studied for its role in anti-aging, and many researchers compare supplier quality, purity, and testing data before purchasing.
What are the research benefits of NAD+?
NAD+ is often evaluated for its potential influence on signaling pathways, recovery support, and targeted research applications. Research interest varies by peptide, formulation, and study design, so buyers typically review purity, dose, and independent lab verification before choosing a source.
How does NAD+ work?
Like other research peptides, NAD+ is typically studied for how it interacts with specific biological pathways and receptor systems. In practice, the way it is formulated, dosed, and tested matters as much as the compound itself, which is why verified suppliers and transparent COAs are important.
Is NAD+ for research use only?
Yes, products like NAD+ are generally intended for research, laboratory, or educational use and are not marketed as approved human therapeutics. Always follow local laws, lab safety practices, and institutional requirements before handling or studying any peptide.
What should I look for before buying NAD+?
Key checks include verified COA data, peptide form and concentration, supplier reputation, stock status, and cost per mg. Comparing pricing and testing records side-by-side helps reduce the risk of buying an under-tested or misrepresented product.

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